Live longer with fewer calories

News: Oct 26, 2011

By consuming fewer calories, ageing can be slowed down and the development of age-related diseases such as cancer and type 2 diabetes can be delayed. The earlier calorie intake is reduced, the greater the effect. Researchers at the University of Gothenburg have now identified one of the enzymes that hold the key to the ageing process.

Mikael Molin, University of Gothenburg.”We are able to show that caloric restriction slows down ageing by preventing an enzyme, peroxiredoxin, from being inactivated. This enzyme is also extremely important in counteracting damage to our genetic material,” says Mikael Molin of the Department of Cell and Molecular Biology.

By gradually reducing the intake of sugar and proteins, without reducing vitamins and minerals, researchers have previously shown that monkeys can live several years longer than expected. The method has also been tested on everything from fishes and rats to fungi, flies and yeasts with favourable results. Caloric restriction also has favourable effects on our health and delays the development of age-related diseases. Despite this, researchers in the field have found it difficult to explain exactly how caloric restriction produces these favourable effects.

Using yeast cells as a model, the research team at the University of Gothenburg has successfully identified one of the enzymes required. They are able to show that active peroxiredoxin 1, Prx1, an enzyme that breaks down harmful hydrogen peroxide in the cells, is required for caloric restriction to work effectively.

Ageing can be delayed

Mikael Molin, University of Gothenburg.The results, which have been published in the scientific journal Molecular Cell, show that Prx1 is damaged during ageing and loses its activity. Caloric restriction counteracts this by increasing the production of another enzyme, Srx1, which repairs Prx1. Interestingly, the study also shows that ageing can be delayed without caloric restriction by only increasing the quantity of Srx1 in the cell. Repair of the peroxiredoxin Prx1 consequently emerges as a key process in ageing.

”Impaired Prx1 function leads to various types of genetic defects and cancer. Conversely, we can now speculate whether increased repair of Prx1 during ageing can counteract, or at least delay, the development of cancer.”

Peroxiredoxins have also been shown to be capable of preventing proteins from being damaged and aggregating, a process that has been linked to several age-related disorders affecting the nervous system, such as Alzheimer’s and Parkinson’s. The researchers are accordingly also considering whether stimulation of Prx1 can reduce and delay such disease processes.

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Gluten-Free Beer

Now thatFootball season has arrived…which means football & friends. For those with celiac disease or a gluten intolerance this doesn’t mean you are left out in the cold while your buddies are cracking open the beers. Gluten-free beer does exist!
One of the key ingredients in beer is barley, which is a definite NO  for those on a gluten free diet. Since the rise in gluten free awareness in the past few years, the food and beverage industry has also followed suit. There are more and more gluten free options available now to accommodate those with celiac disease or a gluten intolerance.

Anheuser Busch, one of the most well known brewing companies in the world, has developed a gluten-free beer called Redbridge. It is made without wheat or barley, so the approximately 3.2 million consumers who are unable to drink beer made with barley due to celiac disease or because they follow a wheat-free or gluten-free diet can once again enjoy a great tasting beer. Redbridge is a rich, full-bodied lager brewed from sorghum for a well-balanced, moderately hopped taste. It is easy to find in larger grocery stores, as well as specialty wine & beer stores

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Salty Snacks That Are Safe…or Are They?

Those of us who love salty snacks think that potato chips, popcorn, nuts and corn tortilla chips are safe foods, right?  We’ve learned to think about the ingredients before we eat, so let’s see potato, oil, salt, nuts, corn, it’s a go!  What a treat to enjoy some of the same snacks we enjoyed before our diagnosis of Celiac Disease. 

As many of us have learned it isn’t that simple most of the time.  Symptoms can show up very quickly or sometimes seem inconsistent.  How could this be, what did we miss?  Further review of the ingredients is typically the answer.  What flavor of salty snacks are you munching on; salt and vinegar, sour cream and onion, fire, nacho cheese or ranch dressing perhaps?  Many times flavorings and spices are to blame.  Wheat flour is being used more and more to help distribute spices and or flavoring over snack items.  

Other additives may be causing problems for those who have gluten sensitivities as well as the general public.  A lot of companies use MSG (Monosodium Glutamate) to enhance the flavor of items they produce. MSG has been linked to headaches, depression, asthma, epilepsy, ADHD and many other health issues.  Moreover most of the symptoms or illnesses brought on by the consumption of this are preventable simply by avoiding MSG.

So what’s the good news here?  All companies are now required to label foods that contain wheat.  Most companies are also providing detailed information about its products and how it relates to food allergies on their website.  Although products may be gluten free it’s possible that it is produced in a facility that processes wheat too.  Those with very high levels of sensitivity need

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wheat allergy or gluten intolerance?

  When you eat wheat do you notice digestive discomfort? Do you ever sneeze, wheeze or have a rash after consuming pizza, bread or other wheat based foods? If so, then you may have a wheat allergy. A wheat allergy is fundamentally different from a gluten intolerance

Wheat Allergy vs. Gluten Intolerance

Unfortunately you will find tons of misleading information on the web where people use the terms wheat allergy, gluten intolerance and even celiac disease interchangeably. However, these are not all the same condition.

  • A Wheat Allergy is a histamine based allergic reaction. When a person with this allergy ingests wheat, a hypersensitive immune system produces antibodies known as IgE (Immunoglobulin E). When histamine stimulates H1 and H2 receptors, it triggers an inflammatory response in your body. Histamine helps dilate blood vessels so that white blood cells (in this case mast cells and basophils, specifically) can fight off the allergy trigger (called the allergen or antigen). As a result, more fluids enter the cells and skin. This causes swelling and other symptoms. An allergy is a type I hypersensitivity, implying it triggers an immediate response. Although most people associate Oral Allergy Syndrome (OAS) with allergies to fruits, nuts and vegetables, a wheat allergy may also manifest as a cross-reactive condition of OAS. Oral Allergy Syndrome is sometimes referred to as Pollen Foods Allergy Syndrome.
  • Celiac Disease is an autoimmune disorder where the immune system of a patient who ingested gluten (a composite protein found in grassy grains like wheat, , rye and barley) produces excessive antibodies (specifically AGA, EMA and Anti-tTG), which attack the walls of the small intestine (and possibly the cerebellum as well — see my Gluten Ataxia guide). Over time, exposure to gluten causes significant damage to the villi (or microvilli) along the lining of the small intestines and can lead to frustrating gastrointestinal problems at first and then serious malnutrition, which then catalyzes a long list of more severe consequences. Celiac disease symptoms include (but are not limited to) nutritional deficiencies like anemia, osteoporosis and weight loss. Some people also experience general digestive distress and indigestion, bloating and alternating bouts of diarrhea and constipation. Celiac disease is a serious condition that can even lead to death if not treated in a timely manner. One problem with identifying celiac disease symptoms is that they may not manifest themselves in an obvious way at first, which leads many people to not understand their condition until serious damage to their small intestine has already begun.
  • Gluten Intolerance, or Gluten Sensitivity, is similar to celiac disease (and many people use the two terms interchangeably, although recent research suggests a gluten sensitivity can manifest as a distinct entity separate from celiac sprue disease), but the difference is that people with gluten intolerance may have similar symptoms to someone with celiac disease, yet they might still have healthy villi in their small intestines. In some cases gluten intolerance is simply an early stage of celiac disease. Until recently, some people believed a non-celiac gluten sensitivity existed, but doctors and researchers remained skeptical. However, first a study in Australia and now a more recent study published in the BMC Medicine Journal finally corroborates this belief with real scientific data. What this means is that one can test negative for the various celiac disease tests (antibody check, intestinal biopsy, and celiac gene check — see gluten intolerance test for more on celiac testing) but still experience some degree of impairing gluten sensitivity.

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Study highlights why we should all look after our blood pressure

people with slightly raised blood pressure may be at a greater risk of a stroke according to a new study from America.

Researchers looked at the results from 12 previous studies. They found that people with a blood pressure reading that was slightly higher than normalhad a greater risk of having a stroke than people with normal blood pressure levels.

While strokes typically affect older people the study also found that middle aged or younger people had a higher risk of developing a stroke if their blood pressure was slightly higher than normal.

Our Senior Cardiac Nurse Maureen Talbot said: “This interesting study supports what we already know, which is the importance of keeping our blood pressure under control whatever our age.

“If a blood pressure reading is borderline, losing some weight and exercising more can often be enough to get things back to normal, but have a chat with your GP if you’re concerned.”

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The prevalence of Celiac Disease in children and young adults

Celiac disease appears to run in families and while once thought to be a rare condition it is now known to be fairly common genetic disorder.  Research shows that when at least one first-degree relative has the disease, between 5% to 10% of their children (and other relatives) will have the same diagnosis.  Most kids are being diagnosed between 6 months and 2 years old.  It is at this point in life where they are getting their first taste of gluten in foods.  

Up to 60% of children can be asymptomatic showing absolutely no symptoms.  Early diagnosis is very important due to a correlation between length of time with the disease and likelihood of developing an autoimmune disorder.  In fact children who are not diagnosed until they are between 2 – 4 years of age have a 10.5% chance of developing an additional autoimmune disorder.  Young adults who learn they have the disease between the ages of 12 – 20 have a significantly increased incidence (27%) of developing another autoimmune condition. 

A majority of teenagers with celiac have learned to adhere to the gluten-free diet.  Some however will have a tough time with it.  Above all they must learn and gain awareness and realize they have a life-long condition for which gluten is harmful.  During puberty celiac disease conditions often appear to lessen or go away.  Thus young adults must understand that once a celiac, always a celiac.

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Too Much Proten can be a Problem?

 team of nutrition researchers and urologic surgeons at Washington University School of Medicine in St. Louis and the Siteman Cancer Center is conducting two studies to investigate a potential link between cancer and excess protein in the diet.

One study targets men with prostate cancer to see whether lowering daily protein intake may slow the growth of cancer before surgery to remove the prostate gland. The second study focuses on men who have had prostate cancer surgery but still have elevated PSA (prostate-specific antigen), a protein produced by prostate cells. Normally men have low levels of PSA in their blood, but prostate cancer can increase the PSA reading. The researchers want to know whether reducing dietary protein can lower prostate cancer risk.

“The typical American diet includes nearly twice the recommended daily allowance for protein, which should be about 10 percent of calories,” says Luigi Fontana, MD, PhD, principal investigator for the studies. “We don’t want to reduce protein below recommended levels, but we want to see whether cutting protein to what’s recommended may improve the health of these patients.”

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Problems with standard tests for gluten intolerance

  • Standard blood tests for gluten intolerance have a less than 30 percent accuracy rate. Would you tolerate that accuracy rate for a cancer, heart disease, or even pregnancy test? Gluten has to have significantly destroyed the gut wall for blood testing to be effective, and for many people that isn’t the case…especially if the brain, heart, or some other part of the body is the main target of attack.
  • Current salivary tests produce false negatives due to the assessment of only one antibody of one wheat protein. Stool tests produce false negative and false positives due to specimen-interfering factors that alter the outcome of results.
  • Current tests only screen for one component of wheat. Yet people can react to a single protein in wheat, or a combination of many proteins, peptides, and enzymes associated with wheat. Some people also have cross-reactivity to gluten. For instance, eating dairy can trigger a gluten-like immune response because the body sees them as one in the same.
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Is gluten harming you?

Gluten has been linked in the literature to 55 diseases so far, most of them autoimmune. The effect of gluten on brain and nervous tissue is significantly worse and more far-reaching than researchers realized. Yet thanks to poor lab testing and general misinformation many people continue to eat gluten, unaware it is harming them.

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Does Gluten Cause Eczema?

Does Gluten Cause Eczema?

 

Eczema is an auto-immune response to a perceived invader. Research indicates that food intolerance affects the immune system. Gluten intolerance and casein intolerance are strongly linked to auto-immune reactions like eczema and other skin problems.

While  Eczema can be caused by many different things. Most people don’t consider that it could be a food they eat all the time. Red, cracked itchy skin can often begin at childhood. If the cause is not investigated it continues for years and the person adjusts to having this skin condition. In fact eczema is one of the most common symptoms of food sensitivity. Sensitivity to wheat, seafood, nuts, eggs, or soy can cause eczema in both children and adults. Recent findings show that Casein from milk products a common cause of eczema. Another common cause of eczema is Gluten (from wheat, rye and barley). In addition Yeast overgrowth is also known to cause chronic eczema in millions of people.

Foods that can cause eczema

Food Intolerance Prevalence
Dairy Intolerance
(includes Lactose intolerance)
~75% 3 in 4 people
Yeast sensitivity
(eg. Candida infections)
~33% 1 in 3 people
Gluten sensitivity
(inc. Celiac and Wheat intolerance)
~15% 1 in 7 people
Fructose or Sugar sensitivity ~35% 1 in 3 people
Food allergy ~1% 1 in 100 people

Approximately 75% of people  are affected by food intolerance. If you are experiencing symptoms it is important to investigate a possible cause. The best way to identify a food intolerance is by  eliminating that food from your diet. If a little understanding and education is applied the cause of the eczema can be quickly revealed.

If it is a food, there is no need to suffer any more. No medications and no therapies needed. Simply leave that food out of your diet – watch your skin improve and stop scratching!

Gini Warner, MA

Clinical Nutritionist

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